Citation
Sk. Sharma et al., Solid-phase total synthesis of polymyxin B1, J PEPT RES, 53(5), 1999, pp. 501-506
Citations number
42
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF PEPTIDE RESEARCH
ISSN journal
1397002X
→ ACNP
Volume
53
Issue
5
Year of publication
1999
Pages
501 - 506
Database
ISI
SICI code
1397-002X(199905)53:5<501:STSOPB>2.0.ZU;2-C
Abstract
The total solid-phase synthesis of polymyxin B1 (PMB1) has been achieved in
20% yield using the orthogonal protecting group N-1-(4,4-dimethyl-2,6-diox
ocyclohexylidene)ethyl-(Dde). This report demonstrates that a complex pepti
de macrocycle can be synthesized in high yields using solid-phase synthesis
. According to MS and HPLC, the synthetic peptide was identical to the natu
rally occurring antibiotic.