Y. Kimya et al., PLASMA INTERLEUKIN-1-ALPHA, INTERLEUKIN-1-BETA AND INTERLEUKIN-1 RECEPTOR ANTAGONIST LEVELS IN PREECLAMPSIA, European journal of obstetrics, gynecology, and reproductive biology, 73(1), 1997, pp. 17-21
The values of plasma interleukin-1 alpha (IL-1 alpha), interleukin-1 b
eta (IL-1 beta) and interleukin-l receptor antagonist (IL-1ra) levels
were evaluated as the markers of pre-eclampsia in 35 serial plasma sam
ples from ten pregnant women who subsequently developed pre-eclampsia
and in 74 plasma samples from 20 uncomplicated pregnancies, retrospect
ively. No correlation was found between plasma IL-1 alpha, IL-1 beta a
nd IL-1ra levels, liver and renal function tests, thrombocyte and whit
e blood cell counts, proteinuria, measured in all systolic and diastol
ic blood pressures and gestational weeks. Almost equal levels of IL-1
alpha and IL-1 beta were corresponding groups, but these were too few
in number to statistically analyze. IL-1ra values were higher in the p
re-eclampsia group than in the uncomplicated pregnancy group, at 20-25
and 31-35 gestational weeks significantly and 26-30 gestational weeks
insignificantly and showed an increase during labor in both groups. I
t was found to have 58% positive predictivity, 100% negative predictiv
ity, 50% specificity and 100% sensitivity at gestational weeks 20-25.
According to these results, IL-1ra seems to be considered for its high
negative predictivity in the exclusion of the probability of pre-ecla
mpsia development during antenatal visits, but its plasma level is not
correlated with the severity of the disease. (C) 1997 Elsevier Scienc
e Ireland Ltd.