Chronic granulocytic leukemia in a dog

Chronic granulocytic leukemia is an uncommon myeloproliferative disorder th at results in substantial proliferation of mature granulocytes. Because the severe leukocytosis and left shift observed with chronic granul ocytic leukemia may strongly resemble a leukemoid reaction, other causes of severe leukocytosis must be ruled out. Myeloid cellular infiltrations may cause hepatomegaly, splenomegaly, or non regenerative anemia and thrombocytopenia. Commonly, results of serum biochemical analyses are only minimally altered or within reference ranges and clinical signs are nonspecific.