CLINICAL AND IMMUNOLOGICAL CONDITION OF NEWBORNS OF MOTHERS TREATED FOR RECURRENT SPONTANEOUS-ABORTIONS WITH PATERNAL LYMPHOCYTES IMMUNIZATION

Objective: The aim of this study was to evaluate the clinical conditio n at birth and some laboratory parameters in newborns of mothers treat ed for recurrent spontaneous abortion (RSA) of unknown etiology with p aternal lymphocytes immunization. Study design: The study comprised 10 4 newborns delivered by 102 women with RSA, who underwent alloimmuniza tion and 90 randomly chosen control newborns. The following parameters were analysed in two groups of newborns: general condition at birth, physical development, course of adaptation period, values of hematolog ical and immunological (percentage of CD3, CD4, CD8, CD19 and CD3/CD25 lymphocytes, chemiluminescence of neutrophils at rest and stimulated with opsonized zymosane) parameters in umbilical arterial blood. Resul ts: No statistically significant differences were noted between the tw o groups of newborns as to the duration of pregnancy, birth weight, ge neral condition at birth, occurrence of complications in the adaptatio n period and values of studied hematological and immunological paramet ers. Conclusion: These results suggest that immunization with paternal lymphocytes in women with RSA of unknown etiology not only creates be tter prognosis for the outcome of the pregnancy, but is also safe for the fetus and the newborn. (C) 1997 Elsevier Science Ireland Ltd.