AUTOANTIBODIES IN RELATION TO RESIDUAL INSULIN-SECRETION IN CHILDREN WITH IDDM

To elucidate whether autoantibodies can be used to predict the intensi ty of autoimmune beta-cell destruction: we determined both C-peptide a nd autoantibodies (islet cell antibodies (TCA), insulin autoantibodies (IAA), islet cell surface antibodies (ICSA) and antibodies to glutami c acid decarboxylase (GADA)), in 89 diabetic children and adolescents at diagnosis at the age of 1.2-16.6 years (mean +/- S.D., 9.0 +/- 4.5) . Only 12/89 (14%) had no autoantibodies at diagnosis, while 2 patient s (2%) had all 4 autoantibodies. There was a positive correlation betw een GADA and ICA (P < 0.01). At diagnosis 70% of the patients had GADA , most common in patients above the age of 8 years at diagnosis (P < 0 .001), and with higher CAD-index in girls (P < 0.05). ICA was detected in 63%, most common in the older age groups (P = 0.04). ICSA seen in 22% of the patients as well as IAA (detected in 32%) were most common < 8 years of age (P = 0.06, P = 0.08, respectively). Children with aut oantibodies had similar C-peptide levels through the follow up period as children of the same sex and age without antibodies, except for pat ients with ICSA alone or in combination with other autoantibodies who tended to have higher C-peptide levels. We conclude that not even comb inations of autoantibodies can be used to predict B-cell destruction i n IDDM patients. (C) 1997 Elsevier Science ireland Ltd.