Ms. Linet et al., Cancer surveillance series: Recent trends in childhood cancer incidence and mortality in the United States, J NAT CANC, 91(12), 1999, pp. 1051-1058
Background: Public concern about possible increases in childhood cancer inc
idence in the United States led us to examine recent incidence and mortalit
y patterns. Methods: Cancers diagnosed in 14540 children under age 15 years
from 1975 through 1995 and reported to nine population-based registries in
the National Cancer Institute's Surveillance, Epidemiology, and End Result
s Program mere investigated. Age-adjusted incidence was analyzed according
to anatomic site and histologic categories of the International Classificat
ion of Childhood Cancer. Age-adjusted U.S, mortality rates were calculated.
Trends in rates were evaluated by use of standard regression methods. Resu
lts: A modest rise in the incidence of leukemia, the most common childhood
cancer, was largely due to an abrupt increase from 1983 to 1984; rates have
decreased slightly since 1989, For brain and other central nervous system
(CNS) cancers, incidence rose modestly, although statistically significantl
y (two-sided P = .020), largely from 1983 through 1986, A few rare childhoo
d cancers demonstrated upward trends (e.g., the 40% of skin cancers designa
ted as dermatofibrosarcomas, adrenal neuroblastomas, and retinoblastomas, t
he latter two in infants only), In contrast, incidence decreased modestly b
ut statistically significantly for Hodgkin's disease (two-sided P = .037).
Mortality rates declined steadily for all major childhood cancer categories
, although less rapidly for brain/CNS cancers. Conclusions: There was no su
bstantial change in incidence for the major pediatric cancers, and rates ha
ve remained relatively stable since the mid-1980s, The modest increases tha
t were observed for brain/CNS cancers, leukemia, and infant neuroblastoma w
ere confined to the mid-1980s, The patterns suggest that the increases like
ly reflected diagnostic improvements or reporting changes. Dramatic decline
s in childhood cancer mortality represent treatment-related improvements in
survival.