Purpose: The beneficial effect of exercise in the retardation of the progre
ssion of cardiovascular disease is hypothesized to be caused, at least in p
art, by the elimination of adverse hemodynamic conditions, including flow r
ecirculation and low wall shear stress. In vitro and in vivo investigations
have provided qualitative and limited quantitative information on flow pat
terns in the abdominal aorta and on the effect of exercise on the eliminati
on of adverse hemodynamic conditions. We used computational fluid mechanics
methods to examine the effects of simulated exercise on hemodynamic condit
ions in an idealized model of the human abdominal aorta.
Methods: A three-dimensional computer model of a healthy human abdominal ao
rta was created to simulate pulsatile aortic blood flow under conditions of
rest and graded exercise. Plow velocity patterns and wall shear stress wer
e computed in the lesion-prone infrarenal aorta, and the effects of exercis
e were determined.
Results: A recirculation zone was observed to form along the posterior wall
of the aorta immediately distal to the renal vessels under resting conditi
ons. Low time-averaged wall shear stress was present in this location, alon
g the posterior wall opposite the superior mesenteric artery and along the
anterior wall between the superior and inferior mesenteric arteries. Shear
stress temporal oscillations, as measured with an oscillatory shear index,
were elevated in these regions. Under simulated Light exercise conditions,
a region of low wall shear stress and high oscillatory shear index remained
along the posterior wall immediately distal to the renal arteries. Under s
imulated moderate exercise conditions, all the regions of low wall shear st
ress and high oscillatory shear index were eliminated.
Conclusion: This numeric investigation provided detailed quantitative data
on the effect of exercise on hemodynamic conditions in the abdominal aorta.
Our results indicated that moderate levels of lower limb exercise are nece
ssary to eliminate the flow reversal and regions of low wall shear stress i
n the abdominal aorta that exist under resting conditions. The lack of flow
reversal and increased wall shear stress during exercise suggest a mechani
sm by which exercise may promote arterial health, namely with the eliminati
on of adverse hemodynamic conditions.