Although infrainguinal arterial reconstruction is best performed with autol
ogous tissue, reconstruction with vein in an infected field has been associ
ated with vein graft disruption and hemorrhage. H.P., a 61-year-old man wit
h peripheral vascular disease, was initially seen with an infected prosthet
ic right femoral-tibioperoneal artery bypass graft. Because of the presence
of purulent drainage from the proximal and distal anastomotic regions and
his comorbidities, a right through-knee guillotine amputation was performed
, followed by graft excision and groin debridement. Right hip and thigh per
fusion was preserved via arterial reconstruction by using a segment of enda
rterectomized popliteal artery, harvested from the amputated extremity. Art
erial reconstruction with autologous tissue from an amputated extremity all
owed us to balance our patient's overall risks with life and tissue preserv
ation. This technique may be applied in the settings of lower extremity isc
hemia, trauma, or malignancy requiring concomitant arterial or venous recon
struction.