Effect of interleukin-2 on the pool of latently infected, resting CD4(+) Tcells in HIV-1-infected patients receiving highly active anti-retroviral therapy
Tw. Chun et al., Effect of interleukin-2 on the pool of latently infected, resting CD4(+) Tcells in HIV-1-infected patients receiving highly active anti-retroviral therapy, NAT MED, 5(6), 1999, pp. 651-655
Citations number
31
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
The size of the pool of resting CD4(+) T cells containing replication-compe
tent HIV in the blood of patients receiving intermittent interleukin (IL)-2
plus highly active anti-retroviral therapy (HAART) was significantly lower
than that of patients receiving HAART alone. Virus could not be isolated f
rom the peripheral blood CD4(+) T cells in three patients receiving IL-2 pl
us HAART, despite the fact that large numbers of resting CD4(+) T cells wer
e cultured. Lymph node biopsies were done in two of these three patients an
d virus could not be isolated. These results indicate that the intermittent
administration of IL-2 with continuous HAART may lead to a substantial red
uction in the pool of resting CD4(+) T cells that contain replication-compe
tent HIV.