Distribution and cellular localization of the serotonin type 2C receptor messenger RNA in human brain

Citation
M. Pasqualetti et al., Distribution and cellular localization of the serotonin type 2C receptor messenger RNA in human brain, NEUROSCIENC, 92(2), 1999, pp. 601-611
Citations number
35
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE
ISSN journal
03064522 → ACNP
Volume
92
Issue
2
Year of publication
1999
Pages
601 - 611
Database
ISI
SICI code
0306-4522(1999)92:2<601:DACLOT>2.0.ZU;2-F
Abstract
The regional and cellular distribution of serotonin type 2C receptor messen ger RNA was investigated in autopsy samples of human brain by ill situ hybr idization histochemistry. The main sites of serotonin receptor type 2C mess enger RNA expression were the choroid plexus, cerebral cortex, hippocampus, amygdala, some components of the basal ganglia, the substantia nigra, the substantia innominata and the ventromedial hypothalamus, suggesting that th is receptor might be involved in the regulation of different brain function s. Interestingly, in all regions examined, the serotonin type 2C receptor m essenger RNA was always restricted to subpopulations of cells, suggesting a specific role, perhaps determined by regionality. A comparison of the in situ hybridization results with those previously obt ained by means of radioligand binding experiments suggested that in most of the areas analysed the serotonin type 2C receptors were located at axon te rminals. (C) 1999 IBRO. Published by Elsevier Science Ltd.