M. Pasqualetti et al., Distribution and cellular localization of the serotonin type 2C receptor messenger RNA in human brain, NEUROSCIENC, 92(2), 1999, pp. 601-611
The regional and cellular distribution of serotonin type 2C receptor messen
ger RNA was investigated in autopsy samples of human brain by ill situ hybr
idization histochemistry. The main sites of serotonin receptor type 2C mess
enger RNA expression were the choroid plexus, cerebral cortex, hippocampus,
amygdala, some components of the basal ganglia, the substantia nigra, the
substantia innominata and the ventromedial hypothalamus, suggesting that th
is receptor might be involved in the regulation of different brain function
s. Interestingly, in all regions examined, the serotonin type 2C receptor m
essenger RNA was always restricted to subpopulations of cells, suggesting a
specific role, perhaps determined by regionality.
A comparison of the in situ hybridization results with those previously obt
ained by means of radioligand binding experiments suggested that in most of
the areas analysed the serotonin type 2C receptors were located at axon te
rminals. (C) 1999 IBRO. Published by Elsevier Science Ltd.