Elimination of manganese is closely related to uptake in the normal adult a
nd is believed to play a critical role in maintaining manganese homeostasis
in the face of changing manganese intake. Data from immature rats, mice an
d cats have suggested that elimination of manganese undergoes a period of m
aturation with adult patterns of excretion developing at about the time of
weaning. In addition, the uptake of manganese from the intestine appears to
be more efficient in young animals than in adults. These two sets of findi
ngs raise the possibility that exposure to elevated manganese levels during
the perinatal period might yield excessive concentrations of this metal in
the developing organism. Such an outcome might lead to manganese accumulat
ions in organ systems where subsequent mobilization might be difficult and
might produce permanent toxic injury. This review evaluates the patterns of
manganese uptake and distribution following prenatal and pre-weaning expos
ure using a variety of model systems. The data demonstrate that manganese d
oes cross the placenta and enter fetal tissue although the extent of materi
al crossing the placenta appears to be limited. The issue of neonatal manga
nese elimination following tracer and toxic exposure levels to manganese is
addressed. The data show that that the neonatal rodent is significantly mo
re effective in eliminating manganese than previously believed based upon t
racer studies. Finally, data are presented on regional brain manganese dist
ribution. These data highlight the lack of agreement on whether manganese i
s concentrated in specific brain areas. (C) 1999 Inter Press, Inc.