Penetration of ofloxacin and ciprofloxacin in aqueous humor after topical administration

Citation
O. Cekic et al., Penetration of ofloxacin and ciprofloxacin in aqueous humor after topical administration, OPHTHAL SUR, 30(6), 1999, pp. 465-468
Citations number
28
Categorie Soggetti
Optalmology
Journal title
OPHTHALMIC SURGERY AND LASERS
ISSN journal
0022023X → ACNP
Volume
30
Issue
6
Year of publication
1999
Pages
465 - 468
Database
ISI
SICI code
0022-023X(199906)30:6<465:POOACI>2.0.ZU;2-5
Abstract
BACKGROUND AND OBJECTIVE: To compare the aqueous humor levels of 0.3% oflox acin and 0.3% ciprofloxacin containing eyedrops in patients with healthy co rnea. PATIENTS AND METHODS: Fifty patients with cataract were randomly assigned t o have 0.3% ofloxacin containing eyedrop (25 patients) or 0.3% ciprofloxaci n containing eyedrop (25 patients). Both drugs were repetitively instilled to each patient for 6 hours before the surgery. Aqueous samples were collec ted after penetrating the anterior chamber during cataract extraction and a ssayed by high-performance liquid chromatography method. RESULTS: The aqueous humor level of ofloxacin (1.43 +/- 0.26 mu g/ml, mean +/- SEM) was significantly higher than that of ciprofloxacin (0.35 +/- 0.07 mu g/ml) following the topical application (P < .0002). CONCLUSION: Aqueous humor penetration of topical ofloxacin is about 4 times higher than that of topical ciprofloxacin when the drugs are applied as de scribed above.