Childhood immunobullous disease following a second organ transplant

Immunobullous diseases are quite unusual in children. We report two childre n who developed immunobullous disease shortly after a second solid organ tr ansplantation. One child had IgA pemphigus vegetans, the other bullous pemp higoid. We hypothesize that the repeat organ transplantation served as a "b ooster" immunization for autoantibody production. Both children developed t heir immunobullous condition while being treated with immunosuppressive dru gs that are used to treat immunobullous disorders.