Jm. Hamby et Hdh. Showalter, Small molecule inhibitors of tumor-promoted angiogenesis, including protein tyrosine kinase inhibitors, PHARM THERA, 82(2-3), 1999, pp. 169-193
Angiogenesis is an exciting and promising new area of research. The concept
that tumor cells are absolutely dependent upon neovascularization to grow
and metastasize has opened the door to a multitude of new approaches and ta
rgets for developing anticancer therapies. These potential new antiangiogen
ic therapies offer the possibility for improved efficacy and reduced toxici
ty relative to conventional cancer treatments without the possibility of dr
ug resistance. In particular, reports of small molecule inhibitors of tumor
-promoted angiogenesis are appearing ever more frequently in the scientific
literature. For this reason, the major focus of this review will be to cov
er small molecule inhibitors of tumor-promoted angiogenesis. The present re
view concentrates on selected literature, principally from mid-1996 to mid-
1998, where there are sufficient biological data to support claims of antia
ngiogenic activities by small molecules. In addition, a historical backgrou
nd is presented and some of the important issues related to this field are
(C) 1999 Elsevier Science Inc. All rights reserved.