Xeroderma pigmentosum variant associated with multiple cancers

Citation
K. Kuwamoto et al., Xeroderma pigmentosum variant associated with multiple cancers, PHOTODERM P, 15(3-4), 1999, pp. 127-132
Citations number
27
Categorie Soggetti
Dermatology
Journal title
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
ISSN journal
09054383 → ACNP
Volume
15
Issue
3-4
Year of publication
1999
Pages
127 - 132
Database
ISI
SICI code
0905-4383(199906/08)15:3-4<127:XPVAWM>2.0.ZU;2-N
Abstract
A 62-year-old Japanese man with xeroderma pigmentosum (XP) variant is repor ted. The patient had developed at least 6 basal cell carcinomas, a squamous cell carcinoma, and a malignant melanoma on sun-exposed areas, and an atyp ical carcinoid on the right lung. In vivo phototesting showed a normal resp onse. The minimal erythema dose of ultraviolet B (UVB) was not lowered and no delayed peaking of the erythema reaction was observed. His skin fibrobla sts exhibited higher sensitivity to UV irradiation, but a normal level of u nscheduled DNA and RNA synthesis. Cell fusions with XP group A, C, D, E, F, and G cells after UV irradiation were all complemented. Previous reports t ogether with this case suggest that older XP variant patients have a high f requency of not only skin cancers, but also internal malignancies.