The notion of meaningful differences between men and women in many aspects
of substance use disorders is a topic that has received increasing attentio
n over the past decade. Before this recent era of investigation, substance
use was considered to be primarily a male problem, and many of the studies
of both alcoholism and drug abuse were conducted with a predominance of mal
e subjects. In this article, the findings concerning gender differences in
key areas related to development, diagnosis, and national trends in substan
ce-use disorders are reviewed.