The effects of cetylpyridinium bromide micelles on the kinetics of alkaline hydrolysis of alkyl p-nitrophenyl chloromethylphosphonate

Study of the kinetics of alkaline hydrolysis of alkyl p-nitrophenyl chlorom ethylphosphonates in micellar solutions of cetylpyridinium bromide showed t hat the observed rate constant depends an the hydrophobicity of the substra tes. A minor increase in the length of the alkyl chain in the substituent i ncreases the catalytic effect in the series Et < Bu < C6H13. Further increa se in the substrate hydrophobicity results in a decrease in the bimolecular rate constant in the micellar phase.