We investigate the issue of testing CPT invariance in the neutral-D sy
stem, using D events obtained either from fixed-target experiments or
from a tau-charm factory. For both types of experiments we show that t
he expected suppression of mixing in the D system, normally viewed as
a disadvantage for CP tests, allows unsuppressed measurement of certai
n parameters describing CPT violation. Asymmetries are presented that
permit the extraction of parameters for direct CPT violation in the D
system and for indirect CPT violation in the K system. We also show th
at experiments on the neutral-D system provide an alternative means fo
r measuring conventional indirect T violation in the kaon system.