The purpose of this study was to describe the ultrasonographic appearance o
f biliary cystadenomas in cats and compare the findings to a similar rare f
orm of liver tumor in humans. Biliary cystadenomas are uncommon, benign liv
er tumors of older cats that may occur as focal or multifocal cystic lesion
s within the liver. The records of 10 cats which had abdominal ultrasonogra
phy and histologic diagnosis of biliary cystadenoma were reviewed. The aver
age age of affected cats was 13.3 years (range 10-16 years). Eight cats wer
e neutered males and two were neutered females. In three cats, the tumors w
ere not seen ultrasonographically due to their small size or from being obs
cured by near-field reverberation echoes. The remaining seven cats had soli
tary (4 cats) or multifocal (3 cats) masses corresponding to variable ultra
sonographic patterns: multilocular masses containing thin-walled cysts, hyp
erechoic masses with cystic components, or masses of mixed echogenicity wit
h cystic components. The masses had variable ultrasonographic patterns when
multifocal disease was present. Recognizable cysts were evident somewhere
within the tumors seen ultrasonographically, although sometimes the cysts a
ppeared very small. The biliary cystadenomas were thought to be clinically
silent. Although liver enlargement or a cranial abdominal mass was palpable
in 4 cats, no consistent trend of clinical signs, CBC or serum biochemical
abnormalities could be directly attributed to biliary cystadenoma. The tre
atment of choice is surgical resection of the tumor, as continued growth ma
y compress adjacent vital structures within the liver. The differential dia
gnosis of biliary cystadenomas from other cystic liver lesions such as hepa
tic cysts, hematomas, abscesses, parasitic cysts, or other liver tumors is
discussed.