Mechanisms of the therapeutic effect of intravenous immunoglobulin

Citation
Rju. Lories et D. Blockmans, Mechanisms of the therapeutic effect of intravenous immunoglobulin, ACT CLIN B, 53(6), 1998, pp. 360-366
Citations number
46
Categorie Soggetti
General & Internal Medicine
Journal title
ACTA CLINICA BELGICA
ISSN journal
00015512 → ACNP
Volume
53
Issue
6
Year of publication
1998
Pages
360 - 366
Database
ISI
SICI code
0001-5512(199812)53:6<360:MOTTEO>2.0.ZU;2-Z
Abstract
Polyclonal immunoglobulins for intravenous use are increasingly used in cli nical practice. The mechanisms involved in the treatment of patients with i mmunodeficiency diseases are not yet clear. In this article we review the m ost important of these mechanisms and we illustrate the use of immunoglobul ins in different diseases. We discuss the interactions with the Fc-receptor s, the interactions with the complement system, the influence on superantig ens, idiotype - anti-idiotype interactions and the influence on B and T cel l receptors. A better understanding of these mechanisms can lead to a bette r use of these expensive preparations.