Mechanisms of the therapeutic effect of intravenous immunoglobulin

Polyclonal immunoglobulins for intravenous use are increasingly used in cli nical practice. The mechanisms involved in the treatment of patients with i mmunodeficiency diseases are not yet clear. In this article we review the m ost important of these mechanisms and we illustrate the use of immunoglobul ins in different diseases. We discuss the interactions with the Fc-receptor s, the interactions with the complement system, the influence on superantig ens, idiotype - anti-idiotype interactions and the influence on B and T cel l receptors. A better understanding of these mechanisms can lead to a bette r use of these expensive preparations.