Synthesis and analgesic activity of some condensed analogs of anpirtoline

Authors
Radl, S Kovarova, L Hezky, P Vosatka, V Konigova, O Proska, J Krejci, I
Citation
S. Radl et al., Synthesis and analgesic activity of some condensed analogs of anpirtoline, ARCH PHARM, 332(6), 1999, pp. 208-212
Citations number
20
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIV DER PHARMAZIE
ISSN journal
03656233 → ACNP
Volume
332
Issue
6
Year of publication
1999
Pages
208 - 212
Database
ISI
SICI code
0365-6233(199906)332:6<208:SAAAOS>2.0.ZU;2-N
Abstract
New condensed derivatives of anpirtoline, in which the pyridine ring is rep laced with quinoline, isoquinoline, quinazoline, and phthalazine nuclei, ha ve been synthesized. Their receptor binding profiles (5-HT1A, 5-HT1B) and a nalgesic activity (hot plate, acetic acid induced writhing) have been studi ed. The analgesic activity of comprounds 7d, 8b, 8c, and 8e are at least co mparable to that of the clinically used drugs flupirtine and tramadol under the same conditions.