3-amino- and 5-aminopyrazoles with anticonvulsant activity

Authors
Lankau, HJ Menzer, M Rostock, A Arnold, T Rundfeldt, C Unverferth, K
Citation
Hj. Lankau et al., 3-amino- and 5-aminopyrazoles with anticonvulsant activity, ARCH PHARM, 332(6), 1999, pp. 219-221
Citations number
6
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIV DER PHARMAZIE
ISSN journal
03656233 → ACNP
Volume
332
Issue
6
Year of publication
1999
Pages
219 - 221
Database
ISI
SICI code
0365-6233(199906)332:6<219:3A5WAA>2.0.ZU;2-E
Abstract
New 3-amino- and 5-aminopyrazoles were synthesised. 3-Aminopyrazoles exert a strong anticonvulsant effect. 4-Chlorophenyl-3-(morpholin-4-yl)-1H-pyrazo le 2 distinctively blocks sodium channels and is strongly effective in the Maximal Electroshock Seizure (MES) test.