Objective: The aim of this ecological study was to examine the relationship
between potential cyanobacterial exposure through drinking water during pr
egnancy and birth outcomes.
Method: One hundred and fifty-six communities in South-Eastern Australia we
re involved, providing 32,700 singleton live newborn during the period 1992
-94. Cyanobacterial occurrence and cell density (alert level) in drinking w
ater sources during the first trimester, the total gestational period for p
remature births or limited to 36 weeks in term infants, and the last 12 wee
ks prior to preterm births or up to and including 36 weeks in term infants
were used as estimates of exposure.
Results: There were statistically significant differences between the propo
rtion of time during the first trimester with cyanobacterial occurrence and
the percentage of births that were low birth weight (LBW) and very low bir
th rate (VLBW). Significant differences were also found among various categ
ories of first trimester exposure based on average cell density and LBW, pr
ematurity and congenital defects. However, the pattern of these results doe
s not suggest a causal link to cyanobacteria. There were no clear dose-resp
onse relationships. Analyses based on exposure during the last 12 weeks and
total gestation also showed no significant dose-response effects.
Conclusion: The results of this study provide no clear evidence for an asso
ciation between cyanobacterial contamination of drinking water sources and
adverse pregnancy outcomes.