Analysis of the mouse MAP1B gene identifies a highly conserved 4.3 kb 3 ' untranslated region and provides evidence against the proposed structure ofDBI-1 cDNA
A. Meixner et al., Analysis of the mouse MAP1B gene identifies a highly conserved 4.3 kb 3 ' untranslated region and provides evidence against the proposed structure ofDBI-1 cDNA, BBA-GENE ST, 1445(3), 1999, pp. 345-350
Citations number
20
Categorie Soggetti
Molecular Biology & Genetics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
We determined the previously unknown 3' end of MAP1B mRNA. We found an unus
ually long and highly conserved 3' untranslated region (3'UTR) of 4.3 kb an
d detected a polymorphism in the 3' flanking region probably due to the int
egration of an endogenous retroviral MuERV-L element. Furthermore, we found
that MAP1B 3'UTR overlapped with the 5' end of the cDNA encoding DBI-1. Ho
wever, further analysis suggested that the published structure of DBI-1 cDN
A is most likely the result of fortuitous joining of unrelated cDNA fragmen
ts during cloning. (C) 1999 Elsevier Science B.V. All rights reserved.