Identification and characterization of mRNAs differentially expressed in thyroid cells stimulated by a mitogenic treatment

The aim of our work is to identify new genes and proteins involved in the c ontrol of the proliferation of thyroid cells as putative protooncogenes and antioncogenes. Several strategies are discussed. A first study has allowed to identify three new genes. Further search will use the differential disp lay and gene arrays methodology. The role of the identified proteins coded by the genes is studied in vit-ro by the search of partner proteins by the double hydrid method and in vivo by mice gene knockout technology. (C) Soci ete francaise de biochimie et biologie moleculaire / Elsevier, Paris.