4,10-dihydro-5H-thieno[3,2-c][1]benzazepine derivatives and 9,10-dihydro-4H-thieno[2,3-c][1]benzazepine derivatives as orally active arginine vasopressin receptor antagonists

Authors
Aranapakam, V Albright, JD Grosu, GT Chan, PS Coupet, J Saunders, T Ru, X Mazandarani, H
Citation
V. Aranapakam et al., 4,10-dihydro-5H-thieno[3,2-c][1]benzazepine derivatives and 9,10-dihydro-4H-thieno[2,3-c][1]benzazepine derivatives as orally active arginine vasopressin receptor antagonists, BIOORG MED, 9(13), 1999, pp. 1733-1736
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
13
Year of publication
1999
Pages
1733 - 1736
Database
ISI
SICI code
0960-894X(19990705)9:13<1733:4DA9>2.0.ZU;2-F
Abstract
Synthesis and structure-activity relationships (SAR) of arginine vasopressi n receptor (AVP) antagonists are described. Potent and orally active compou nds are prepared when tricyclic 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodi azepine moiety in VPA-985 1 is replaced with a compound 7 or 12. (C) 1999 E lsevier Science Ltd. All rights reserved.