5-fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4] benzodiazepine-10(11H)-YL carbonyl)-2-pyridinyl] benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists

Authors
Aranapakam, V Albright, JD Grosu, GT Santos, EGD Chan, PS Coupet, J Ru, X Saunders, T Mazandarani, H
Citation
V. Aranapakam et al., 5-fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4] benzodiazepine-10(11H)-YL carbonyl)-2-pyridinyl] benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists, BIOORG MED, 9(13), 1999, pp. 1737-1740
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
13
Year of publication
1999
Pages
1737 - 1740
Database
ISI
SICI code
0960-894X(19990705)9:13<1737:5BC>2.0.ZU;2-5
Abstract
Synthesis and structure-activity relationships (SAR) of orally active argin ine vasopressin (AVP) receptor antagonists are discussed. Potent and orally active AVP receptor antagonists are produced when ring A of VPA-985 (1) is replaced with a 3-pyridinyl unit (2b). (C) 1999 Elsevier Science Ltd. All rights reserved.