Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides

Authors
Strekowski, L Zegrocka, O Henary, M Say, M Mokrosz, MJ Kotecka, BM Manzel, L Macfarlane, DE
Citation
L. Strekowski et al., Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides, BIOORG MED, 9(13), 1999, pp. 1819-1824
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
13
Year of publication
1999
Pages
1819 - 1824
Database
ISI
SICI code
0960-894X(19990705)9:13<1819:SRAOS4>2.0.ZU;2-B
Abstract
On the basis of a systematic SAR analysis of substituted quinolines, a deri vative 32 was synthesized that shows half-maximal inhibition of the immunos timulatory effect of CpG-oligodeoxynucleotides in vitro at the concentratio n of 0.24 nM. (C) 1999 Elsevier Science Ltd. All rights reserved.