L. Strekowski et al., Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides, BIOORG MED, 9(13), 1999, pp. 1819-1824
On the basis of a systematic SAR analysis of substituted quinolines, a deri
vative 32 was synthesized that shows half-maximal inhibition of the immunos
timulatory effect of CpG-oligodeoxynucleotides in vitro at the concentratio
n of 0.24 nM. (C) 1999 Elsevier Science Ltd. All rights reserved.