From histamine to imidazolylalkyl-sulfonamides: The design of a novel series of histamine H-3-receptor antagonists.

Authors
Tozer, MJ Harper, EA Kalindjian, SB Pether, MJ Shankley, NP Watt, GF
Citation
Mj. Tozer et al., From histamine to imidazolylalkyl-sulfonamides: The design of a novel series of histamine H-3-receptor antagonists., BIOORG MED, 9(13), 1999, pp. 1825-1830
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
13
Year of publication
1999
Pages
1825 - 1830
Database
ISI
SICI code
0960-894X(19990705)9:13<1825:FHTITD>2.0.ZU;2-Q
Abstract
Histamine was converted to a selective histamine Hs-receptor antagonist by capping the primary amine with 2-naphthalenesulfonyl chloride. Higher recep tor affinity and lower variability in the data from the various bioassays w ere achieved with the 2-naphthalensulfonamides of histamine homologues. (C) 1999 Elsevier Science Ltd. All rights reserved.