Lipase-catalysed acylation of prostanoids

Authors
Parve, O Jarving, I Martin, I Metsala, A Vallikivi, I Aidnik, M Pehk, T Samel, N
Citation
O. Parve et al., Lipase-catalysed acylation of prostanoids, BIOORG MED, 9(13), 1999, pp. 1853-1858
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
13
Year of publication
1999
Pages
1853 - 1858
Database
ISI
SICI code
0960-894X(19990705)9:13<1853:LAOP>2.0.ZU;2-C
Abstract
Natural prostaglandins (PG) F-2 alpha and E-1 as well as (+)-cloprostenol w ere regioselectively Il-acylated using Novozym(R) 435 as a catalyst and vin yl acetate as an acyl donor. Unlike the above compounds the 15-OH group of PGE(2) was also acylated with a significant velocity under the same conditi ons. The enantiospecificity of the lipase-catalysed 11-acetylation of clopr ostenol was established by separate treatment of (+)- and (-)-cloprostenols . (C) 1999 Elsevier Science Ltd. All rights reserved.