R. Verpoorte et al., Metabolic engineering of plant secondary metabolite pathways for the production of fine chemicals, BIOTECH LET, 21(6), 1999, pp. 467-479
The technology of large-scale plant cell culture is feasible for the indust
rial production of plant-derived fine chemicals. Due to low or no productiv
ity of the desired compounds the economy is only in a few cases favorable.
Various approaches are studied to increase yields, these encompass screenin
g and selection of high producing cell lines, media optimization, elicitati
on, culturing of differentiated cells (organ cultures), immobilization. In
recent years metabolic engineering has opened a new promising perspectives
for improved production in a plant or plant cell culture.