The intrastratial injection of an adenosine A(2) receptor antagonist prevents frontal cortex EEG abnormalities in a rat model of Huntington's disease

Authors
Reggio, R Pezzola, A Popoli, P
Citation
R. Reggio et al., The intrastratial injection of an adenosine A(2) receptor antagonist prevents frontal cortex EEG abnormalities in a rat model of Huntington's disease, BRAIN RES, 831(1-2), 1999, pp. 315-318
Citations number
22
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
831
Issue
1-2
Year of publication
1999
Pages
315 - 318
Database
ISI
SICI code
0006-8993(19990612)831:1-2<315:TIIOAA>2.0.ZU;2-3
Abstract
The influence of 3,7-dimethyl-1-propargylxanthine (DMPX) an adenosine A(2) receptor antagonist, was studied in the quinolinic acid (QA) model of Hunti ngton's disease. Male Wistar rats received bilateral intrastriatal injectio ns of QA (300 nmol) alone or plus DMPX (0.02, 0.2 and 2 mu g). At the dose of 0.2 mu g, DMPX completely prevented QA-induced EEG abnormalities at the level of frontal cortex. The results support the hypothesis of a neuroprote ctive role of adenosine A(2) receptor antagonists. (C) 1999 Elsevier Scienc e B.V. All rights reserved.