What might a stromal response mean to prostate cancer progression ?

Authors
Citation
Dr. Rowley, What might a stromal response mean to prostate cancer progression ?, CANC METAST, 17(4), 1998, pp. 411-419
Citations number
80
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER AND METASTASIS REVIEWS
ISSN journal
01677659 → ACNP
Volume
17
Issue
4
Year of publication
1998
Pages
411 - 419
Database
ISI
SICI code
0167-7659(1998)17:4<411:WMASRM>2.0.ZU;2-N
Abstract
Many similarities exist between the stroma at sites of wound repair and rea ctive stroma in cancer. Common features include an elevated stromal cell pr oliferation, altered expression of matrix components, elevated expression o f TGF beta-1, neovascularization, and expression of several common stromal markers. In addition, proliferative stromal cells at these sites generally express myodifferentiation markers. A comparison between the many common fe atures and the biologically active molecules observed in reactive stroma in carcinoma and reactive stroma in wound repair is discussed in this review. An extended analysis of the literature suggests a functional link between mechanisms in wound repair response and the stromal reaction in many cancer s including prostate cancer. We propose in this review, that the fundamenta l mechanisms of stroma in providing a rapid response to altered homeostasis in wounding, also provides for a tumor-regulating stromal microenvironment in cancer. The functional consequences of this stromal response to carcino ma progression and how the stromal response might be used in extended diagn osis and in therapeutic approaches are discussed.