Pretargeting with the Affinity Enhancement System for radioimmunotherapy

The pretargeting technique referred to as the Affinity? Enhancement System (AES) uses bispecific antibodies and radiolabeled bivalent haptens that bin d cooperatively to target cells in vivo. Experimental and clinical data dem onstrate that AES can deliver large radiation doses to tumor cells with hig h tumor to normal tissue contrast ratios and long activity residence time i n tumors Preliminary clinical results of radioimmunotherapy of medullary th yroid carcinomas and lung cancers look promising.