Fibrinolytic therapy and n-acetylocysteine in the treatment of patients with acute myocardial infarction: Its influence on authentic plasma hydroperoxide levels and polymorphonuclear neutrophil oxygen metabolism
A. Sajkowska et al., Fibrinolytic therapy and n-acetylocysteine in the treatment of patients with acute myocardial infarction: Its influence on authentic plasma hydroperoxide levels and polymorphonuclear neutrophil oxygen metabolism, CARDIOLOGY, 91(1), 1999, pp. 60-65
Citations number
20
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Recently it has been demonstrated that the administration of n-acetylocyste
ine (NAC), in combination with streptokinase, significantly diminished oxid
ative stress in patients with myocardial infarction. The aim of our study w
aste assess the influence of NAC treatment, as adjunct therapy in an evolvi
ng myocardial infarction, on the polymorphonuclear count, superoxide anion
and hydrogen peroxide levels and nitric oxide production by PMNs and authen
tic: plasma hydroperoxide (ROOH). Treatment of patients with NAC in additio
n to reperfusion therapy was accompanied by a significant decrease in the n
umber of circulating polymorphonuclear neutrophils. However, the oxygen met
abolism of PMNs was not affected by NAC administration. The concentration o
f authentic plasma hydroperoxide was significantly reduced by the administr
ation of NAC which suggests diminished oxidative stress during acute myocar
dial infarction.