Sex differences in strategies of coping with novel situations were stu
died in three strains of mice with regard to metabolism and open-field
and maze activity as well as learning-induced adjustment. The 140 mic
e were selectively bred for high (Turku Aggressive [TA]) and low (Turk
u Nonaggressive [TNA]) levels of aggressiveness and originated from a
Swiss albino stock normally distributed [N] for aggressiveness. The re
sults indicated that TNA sex differences are more similar to those of
the control N mice as compared to those of TA mice. In maze learning,
however, the sex differences of TA mice are more in agreement with tho
se of the N strain. Recordings of metabolism and open-field as well as
maze activity were correlates of both gen der and strain. Sex differe
nces in learning-induced open-field coping behavior were unrelated to
strain.