Synthesis of (1-azabicyclo[3.3.0]octanyl)methyl-substituted aromatic heterocycles and their muscarinic activity

Authors
Suzuki, T Uesaka, H Hamajima, H Ikami, T
Citation
T. Suzuki et al., Synthesis of (1-azabicyclo[3.3.0]octanyl)methyl-substituted aromatic heterocycles and their muscarinic activity, CHEM PHARM, 47(6), 1999, pp. 876-879
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
47
Issue
6
Year of publication
1999
Pages
876 - 879
Database
ISI
SICI code
0009-2363(199906)47:6<876:SO(AH>2.0.ZU;2-A
Abstract
In our development of drugs effective against Alzheimer's disease, we have researched a series of aromatic compounds having a characteristic cyclic am ine, 1-azabicyclo[3.3.0]octane ring. In this report, we describe synthesis of a series of aromatic heterocycles with the 1-azabicyclo[3.3.0]octane ring and their pharmacological evaluatio n. 3-Amino-5-(1-azabicyclo[3.3.0]octan-5-yl)methyl-1,2,4-oxadiazole (2b) sh owed the highest M-1 selectivity.