A. Sreedhara et al., Novel reagents for targeted cleavage of RNA sequences: towards a new family of inorganic pharmaceuticals, CHEM COMMUN, (12), 1999, pp. 1147-1148
Copper kanamycin degrades cognate RNA targets at concentrations as low as p
icomolar levels at physiological pH and temperature, but shows no chemistry
with random RNA or DNA molecules, thereby demonstrating potential for deve
lopment as a novel antiviral agent.