Novel reagents for targeted cleavage of RNA sequences: towards a new family of inorganic pharmaceuticals

Citation
A. Sreedhara et al., Novel reagents for targeted cleavage of RNA sequences: towards a new family of inorganic pharmaceuticals, CHEM COMMUN, (12), 1999, pp. 1147-1148
Citations number
24
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
12
Year of publication
1999
Pages
1147 - 1148
Database
ISI
SICI code
1359-7345(19990621):12<1147:NRFTCO>2.0.ZU;2-H
Abstract
Copper kanamycin degrades cognate RNA targets at concentrations as low as p icomolar levels at physiological pH and temperature, but shows no chemistry with random RNA or DNA molecules, thereby demonstrating potential for deve lopment as a novel antiviral agent.