Studies on synthesis and degradation properties of polyanhydrides with hexestrol in the backbone

Polymeric drug containing active agent in the backbone was one of the contr olled release systems. In this paper, some polymers, which have an antineop lastic agent(hexestrol) in the backbone, have been synthesized by copolymer ization hexestrol bis(hydrogen succinate) with sebacic acid(SA). Hexestrol bis(hydrogen succinate) was prepared by reaction hexestrol with succinic an hydride. The degradation properties in vitro under various pH conditions we re also investigated. The results showed that the degradation rates increas e with the increase of PH, and at the same time, the degradation rates incr ease with the increase in sebacic acid content in the copolymers.