The trithorax-group and Polycomb-group chromatin modifiers: implications for disease

Authors
van Lohuizen, M
Citation
M. Van Lohuizen, The trithorax-group and Polycomb-group chromatin modifiers: implications for disease, CUR OP GEN, 9(3), 1999, pp. 355-361
Citations number
72
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
9
Issue
3
Year of publication
1999
Pages
355 - 361
Database
ISI
SICI code
0959-437X(199906)9:3<355:TTAPCM>2.0.ZU;2-S
Abstract
The chromatin structure associated transcriptional memory function by Polyc omb-group and trithorax-group protein complexes integrate normal developmen t with control of cellular proliferation. This is illustrated by recent mec hanistic insights that link Polycomb repression with histone deacetylases a nd the identification of new target genes that provide a connection to cell cycle control and tumorigenesis.