Lichenoid cutaneous drug reaction at injection sites of granulocyte colony-stimulating factor (filgrastim)

Citation
Am. Viallard et al., Lichenoid cutaneous drug reaction at injection sites of granulocyte colony-stimulating factor (filgrastim), DERMATOLOGY, 198(3), 1999, pp. 301-303
Citations number
12
Categorie Soggetti
Dermatology
Journal title
DERMATOLOGY
ISSN journal
10188665 → ACNP
Volume
198
Issue
3
Year of publication
1999
Pages
301 - 303
Database
ISI
SICI code
1018-8665(1999)198:3<301:LCDRAI>2.0.ZU;2-X
Abstract
Colony-stimulating factors are widely used for bone marrow recovery after c hemotherapy. Various cutaneous side-effects have been described in most cas es involving neutrophils. We report the first case of lichenoid reaction at injection sites of granulocyte colony-stimulating factor (G-CSF) in a 40-y ear-old patient treated for breast cancer. The eruption cleared after drug withdrawal, no recurrence was observed after drug replacement by granulocyt e-macrophage colony-stimulating factor. Mainly lymphocyte-mediated lichenoi d eruption to G-CSF was shown. Cutaneous side-effects to G-CSF do not share unequivocal pathogeny based on stimulation of neutrophils.