Prevalence of "syndrome X" features in parents of type 1 diabetic patientswith or without nephropathy

OBJECTIVE - To compare the prevalence of "syndrome X"-related parameters in parents of type 1 diabetic patients with diabetic nephropathy (DNP) to tho se in parents of diabetic patients without DNP! RESEARCH DESIGN AND METHODS - In this cross-sectional study we included 50 parents of type 1 diabetic patients with DNP and 50 parents of diabetic pat ients without DNP. All parents were investigated in a fasting state for ser um lipids including nonesterified fatty acids (NEFAs), glucose, HbA(1c), pl asma uric acid, Easting insulin levels, and albuminuria. Blood pressure was recorded in the supine position using an automatic device; ankle/brachial index was measured with Doppler ultrasound. Presence of cardiovascular dise ase was determined by a standardized questionnaire and electrocardiogram re gistration. Subjects without known diabetes underwent a 2-h oral glucose to lerance test. Anthropometric parameters such as BMI, waist-to-hip ratio, an d percentage of body fat were measured. In addition to univariate analysis, a syndrome X score (SXS) was formulated, comprising a number of syndrome X -related biochemical, physiological, and/or anthropometric parameters. RESULTS - Univariate analysis revealed no significant differences in syndro me X parameters between parents of type 1 diabetic patients with or without DNP. Also, the composite SXS was similar in both groups. CONCLUSIONS - In this study Ilo differences were found in the prevalence of syndrome X features between parents of type 1 diabetic patients with DNP a nd parents of patients without DNP.