Analysis and a long-term follow up of ketosis-onset Japanese NIDDM patients

It has been reported that excessive intake of sugar-containing soft drinks results in diabetic ketoacidosis (DKA) or ketosis (DK) in obese patients wi th nun-insulin dependent diabetes mellitus (NIDDM). We describe the clinica l characteristics;:nd results of long-term follow-up for 24 newly-diagnosed patients with acute-onset NIDDM presenting with DKA Or DK. A history of ex cessive intake of sugar-containing soft drinks was found in 19 (Group A); s erious non-diabetic illnesses were found in 5 (Group B). The: range of pati ent a ges in Group A was 16 to 57 years while all patients in Group B were 60 years or older. In Group A. no patient was positive for autoantibodies, specific HLAs for Japanese insulin dependent diabetes mellitus, or mutation of the beta-3-adrenergic receptor gene. The body mass indices (BMIs) at on set and admission and serum C-peptide immunoreactivities at admission and d ischarge were significantly higher in patients in Group A than in patients Group B. Tn conclusion, we reconfirmed that excessive intake of sugar-conta ining soft drinks is one of the contributing factors in DKA or DK-onset NID DM patients. We found no autoimmune mechanism involved in the pathogenesis and that a polymorphism in the beta-3-adrenergic receptor gene could be ass ociated with the development of soft-drink ketosis. (C) 1999 Elsevier Scien ce Ireland Ltd. All rights reserved.