alpha 1,3-fucoslytransferase IX (Fuc-TIX) is very highly conserved betweenhuman and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX

Authors
Kaneko, M Kudo, T Iwasaki, H Ikehara, Y Nishihara, S Nakagawa, S Sasaki, K Shiina, T Inoko, H Saitou, N Narimatsu, H
Citation
M. Kaneko et al., alpha 1,3-fucoslytransferase IX (Fuc-TIX) is very highly conserved betweenhuman and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX, FEBS LETTER, 452(3), 1999, pp. 237-242
Citations number
40
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FEBS LETTERS
ISSN journal
00145793 → ACNP
Volume
452
Issue
3
Year of publication
1999
Pages
237 - 242
Database
ISI
SICI code
0014-5793(19990611)452:3<237:A1I(IV>2.0.ZU;2-#
Abstract
The amino acid sequence of Fuc-TIX is very highly conserved between mouse a nd human. The number of nonsynonymous nucleotide substitutions of the Fuc-T IX gene between human and mouse was strikingly low, and almost equivalent t o that of the alpha-actin gene. This indicates that Fuc-TIX is under a stro ng selective pressure of preservation during evolution, The human Fuc-TIX ( hFuc-TIX) showed a unique characteristics, i.e. hFuc-TIX was not activated by Mn2+ and Co2+, whereas hFuc-TIV and hFuc-TVI were activated by the catio ns, The hFuc-TIX transcripts were abundantly expressed in brain and stomach , and interestingly were detected in spleen and peripheral blood leukocytes , (C) 1999 Federation of European Biochemical Societies.