alpha 1,3-fucoslytransferase IX (Fuc-TIX) is very highly conserved betweenhuman and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX
Authors
Kaneko, M
Kudo, T
Iwasaki, H
Ikehara, Y
Nishihara, S
Nakagawa, S
Sasaki, K
Shiina, T
Inoko, H
Saitou, N
Narimatsu, H
Citation
M. Kaneko et al., alpha 1,3-fucoslytransferase IX (Fuc-TIX) is very highly conserved betweenhuman and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX, FEBS LETTER, 452(3), 1999, pp. 237-242
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FEBS LETTERS
SICI code
0014-5793(19990611)452:3<237:A1I(IV>2.0.ZU;2-#
Abstract
The amino acid sequence of Fuc-TIX is very highly conserved between mouse a
nd human. The number of nonsynonymous nucleotide substitutions of the Fuc-T
IX gene between human and mouse was strikingly low, and almost equivalent t
o that of the alpha-actin gene. This indicates that Fuc-TIX is under a stro
ng selective pressure of preservation during evolution, The human Fuc-TIX (
hFuc-TIX) showed a unique characteristics, i.e. hFuc-TIX was not activated
by Mn2+ and Co2+, whereas hFuc-TIV and hFuc-TVI were activated by the catio
ns, The hFuc-TIX transcripts were abundantly expressed in brain and stomach
, and interestingly were detected in spleen and peripheral blood leukocytes
, (C) 1999 Federation of European Biochemical Societies.
