Objective: The authors examined different ways of measuring unit costs
and how methodological assumptions can affect the magnitude of cost e
stimates and the ratio of treatment costs in comparative studies of me
ntal health interventions. Four methodological choices may bias cost e
stimates: study perspective, definition of the opportunity cost of res
ources, cost allocation rules, and measurement of service units. Metho
d: Unit costs for outpatient services, individual therapy, and group t
herapy were calculated under different assumptions for a single commun
ity mental health center (CMHC). Using hypothetical service utilizatio
n profiles, the authors used the unit costs to calculate the costs of
mental health treatments provided by two programs of the CMHC. Results
: The unit costs for an hour of outpatient services ranged from $108 t
o $538. The unit costs for an hour of therapy varied by 156%; unit cos
ts were lowest if the management perspective was assumed and highest i
f the economist perspective was assumed. The ratio of the outpatient c
osts in the two treatment programs ranged from 0.6 to 1.8. Conclusions
: The potential errors introduced by methodological choices can bias c
ost-effectiveness findings based on randomized control trials. These e
rrors go undetected because crucial methodological information is not
reported.