CD4(+) T cells which react to the Leishmania major LACK antigen rapidly secrete interleukin-4 and are detrimental to the host in resistant B10.D2 mice

Authors
Julia, V Glaichenhaus, N
Citation
V. Julia et N. Glaichenhaus, CD4(+) T cells which react to the Leishmania major LACK antigen rapidly secrete interleukin-4 and are detrimental to the host in resistant B10.D2 mice, INFEC IMMUN, 67(7), 1999, pp. 3641-3644
Citations number
26
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
67
Issue
7
Year of publication
1999
Pages
3641 - 3644
Database
ISI
SICI code
0019-9567(199907)67:7<3641:CTCWRT>2.0.ZU;2-T
Abstract
Leishmania major induces the rapid production of interleukin-4 (IL-4) in bo th susceptible BALB/c and resistant B10.D2 mice. In both strains,IL-4 is pr oduced by T cells which react to the parasite LACK (for Leishmania homolog of the receptor for activated C kinase) antigen. The rapid production of IL -4 in B10.D2 mice does not confer susceptibility but results in increased p arasite burdens.