RECENT ADVANCES IN HEMOSTATIC RISK-FACTORS AND CARDIOVASCULAR-DISEASES

Population-based and clinical prospective studies have clearly establi shed plasma fibrinogen levels as an independent risk factor for CHD ev ents. Cross-sectional analysis further reveals that plasma fibrinogen levels are independently associated with asymptomatic carotid atherosc lerosis. Factor VII, Factor VIII, VWF, tPA, PAI-1, and markers of plat elet activation are potentially associated with CHD events and/or asym ptomatic atherosclerosis. Recent advances in this field of research ha s provided an excellent opportunity of studying the causal relationshi p between hemostatic factors and CHD events.