Extragonadal germ cell tumor of the prostate associated with Klinefelter'ssyndrome

Purpose: We report on a case of extragonadal germ cell tumor of the prostat e associated with Klinefelter's syndrome. Methods/Results: The patient was a 33-year-old man. A transrectal prostate biopsy suggested combined germ ce ll tumor (yolk sac tumor + teratoma). Because there was no tumor except fro m the prostate, we considered this case to be a primary extragonadal germ c ell tumor of the prostate. The prostate tumor responded to systemic chemoth erapy with cisplatin, vinblastine and bleomycin and elevated lactate dehydr ogenase and alpha-fetoprotein levels normalized. In addition to chemotherap y, the patient also underwent radiation therapy. Conclusion: The patient ha s survived for approximately 4 years since the diagnosis.