In this paper we propose a method for the regularization of inverse problem
s whose solutions are known to exhibit anisotropic characteristics. The met
hod is based on the generalized Tikhonov regularization and on the spatial
prior information on the underlying solution. We allow the prior informatio
n to be only of approximate nature. In the proposed method, the prior infor
mation is incorporated into the regularization operator with the aid of a p
roperly constructed matrix-valued field. Although the approach is determini
stic it also has a clear statistical interpretation that will be discussed
from the Bayesian viewpoint. The method is applied to two examples, the fir
st is the inversion of a Fredholm integral equation of the first kind and t
he second is a case study of electrical impedance tomography (EIT).