Lipase-catalyzed kinetic resolution of 2,3-epoxy-1-tridecanol and its application to facile synthesis of (+)-Disparlure

Authors
Fukusaki, EI Satoda, S Senda, S Omata, T
Citation
Ei. Fukusaki et al., Lipase-catalyzed kinetic resolution of 2,3-epoxy-1-tridecanol and its application to facile synthesis of (+)-Disparlure, J BIOSCI BI, 87(1), 1999, pp. 103-104
Citations number
7
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
ISSN journal
13891723 → ACNP
Volume
87
Issue
1
Year of publication
1999
Pages
103 - 104
Database
ISI
SICI code
1389-1723(199901)87:1<103:LKRO2A>2.0.ZU;2-J
Abstract
Acylation of (+/-)-2,3-epoxy-1-tridecanol with acetic anhydride in diisopro pyl ether by porcine pancreatic lipase yielded (2R, 3S)-2,3-epoxy-1-trideca nol as the remaining substrate with an optical purity of over 99% ee. (+)-D isparlure was synthesized in two steps from this optically active epoxy alc ohol.